Diphenhydramine for the Treatment of Motion Sickness

by Motion Sickness.net

Drugs-CapsulesDiphenhydramine (DYE-fen-HYE-dra-meen)

Common Drug Names

  • Aler-Dryl
  • Aler-Tab
  • Allermax
  • Altaryl
  • Banophen
  • Ben-Tann
  • Benadryl
  • Benadryl Allergy
  • Benadryl Children’s Allergy
  • Calm-Aid
  • Dicopanol
  • Diphendryl
  • Diphen
  • Diphenhist
  • Dytan
  • Dytuss
  • Genahist
  • Hydramine
  • Nu-Med
  • Q-Dryl
  • Q-Dryl A/F
  • Quenalin
  • Siladryl
  • Siladryl Allergy
  • Silphen Cough
  • Twilite
  • Valu-Dryl

Typically Used For

Acts as an antihistamine. Histamine is a substance that is produced by your body which triggers sneezing, runny nose, watery eyes, and itching. Antihistamines, on the other hand, help to combat these symptoms by reducing or blocking your body’s ability to produce histamine.

Standard Warnings

  • Talk with your doctor prior to taking this medication if you are currently breast-feeding, are pregnant, or are planning on becoming pregnant soon.
  • Tell your doctor what current prescribed and non-prescribed drugs, herbs, vitamins, and/or supplements you are taking (Note: You should always keep a list of this information handy for future use).
  • Use as directed per the packaging instructions unless otherwise directed by a medical professional.
  • Do not start, stop, or change the dosage of this medication unless otherwise directed by your health care provider.
  • Tell your doctor or medical professional if you have any allergic reactions to this or any other medications.

Specific Warnings

  • Do not take this medicine if you are taking or have been prescribed Sodium Oxybate (GHB) as this may cause reactions with Diphenhydramine including an increase in the amount of time that you sleep and/or a decrease in your ability to breathe.
  • Do not take with Monoamine Oxidase Inhibitors – MAOs (e.g., phenelzine). MAOs are a form of antidepressant which may cause serious side effects when used with Diphenhydramine including high blood pressure or seizure.
  • Do not take if you are breast feeding unless otherwise directed by your medical professional.
  • Tell your doctor if you are also currently taking antibiotics or antispasmodics as they may interfere with Diphenhydramine.


  • Avoid taking alcohol with this medication.
  • Take with food if the medication causes an upset stomach.  Otherwise, the medication can be taken with or without food.
  • Typical dosage is one table usually every 4 to 6 hours.  However, follow all directions on the packaging or the directions provided to you by your medical practitioner.
  • Take 30 minutes before travel or before you expect your motion sickness symptoms to likely occur.

Some Common Side Effects

  • May include dry mouth (xerostomia), drowsiness, dizziness.
  • Do not use heavy machinery or drive until you know how this medication affects you.
  • Like all medications, allergic reactions may result.  If an allergic reaction does occur, talk with your doctor or immediately seek medical attention.
  • There may be and likely are additional side effects not described above.  Please talk with your medical professional if you are curious about other potential side effects


The information described above is for informational purposes only (please visit our medical disclaimer page here for more information).  The information on this page merely provides a quick summary related to this particular drug.  Please speak with your doctor, pharmacist, and/or health care provider before using, starting to take, or changing the dosage of this medication.

Feel Free to Comment on this Drug

If you have any reviews or comments on this particular drug in terms of treating motion sickness, please place them in the comment section below for our other readers. Thanks!

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